2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer

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Updated: Jun 1, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Sanjay Mandal1, Fisseha Abebe, Jaideep Chaudhary

  • 1Center For Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta, Georgia 30314, USA.

Cancer
|June 4, 2011
PubMed
Abstract

Insights

The OAS1 rs2660 AA genotype significantly increases prostate cancer risk, while the GG genotype offers protection. This OAS1 polymorphism may influence cancer development and progression.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • The 2'-5' oligoadenylate synthetase (2-5OAS1) gene plays a role in antiviral and antiproliferative pathways.
  • A specific polymorphism in OAS1 (rs2660) affects enzyme activity and has been linked to disease susceptibility.
  • The adenine-adenine (AA) genotype is generally associated with lower enzyme activity and increased susceptibility, while the guanosine-guanosine (GG) genotype is linked to higher activity and protection.

Purpose of the Study:

  • To investigate the association between the functional OAS1 polymorphism (rs2660) and prostate cancer risk.
  • To determine if specific genotypes of OAS1 rs2660 influence susceptibility or protection against prostate cancer.

Main Methods:

  • Case-control genetic association study.
  • Genotyping of OAS1 SNPs rs2660, rs1131454, and rs34137742 in 164 prostate cancer cases and 140 controls.
  • Statistical analysis using logistic regression.

Main Results:

  • A significant association was found between the OAS1 rs2660 genotype and prostate cancer.
  • The AA genotype was linked to an increased risk of prostate cancer, particularly with age.
  • The GG genotype was associated with a decreased risk of prostate cancer; this genotype was not observed in African American samples.

Conclusions:

  • The OAS1 rs2660 polymorphism, specifically the AA genotype, is significantly associated with increased prostate cancer risk.
  • The GG genotype appears to be protective against prostate cancer.
  • This functional OAS1 SNP may impact prostate cancer development by affecting OAS1-RNaseL pathway function and cellular processes like growth and apoptosis.

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