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Updated: Jun 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Effect of cardiac resynchronization therapy on libido and erectile dysfunction
Ahmet Vural1, Aysen Agacdiken, Umut Celikyurt
1Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, Turkey.
Insights
Cardiac resynchronization therapy (CRT) significantly improves sexual function in men with chronic heart failure (HF). This therapy enhances libido and erectile function, positively impacting quality of life for HF patients.
Area of Science:
- Cardiology
- Sexual Medicine
- Medical Devices
Background:
- Chronic heart failure (HF) is a prevalent condition associated with reduced quality of life, including decreased libido and erectile dysfunction (ED).
- The impact of cardiac resynchronization therapy (CRT) on sexual function in HF patients has not been previously investigated.
- Understanding these effects is crucial for comprehensive patient care.
Purpose of the Study:
- To evaluate the efficacy of cardiac resynchronization therapy (CRT) in improving libido and erectile function (ED) in male patients with advanced heart failure (HF).
Main Methods:
- A cohort of 31 male patients with advanced HF undergoing CRT implantation were assessed.
- Libido and ED were evaluated using the Aging Male Symptoms (AMS) rating scale and the Sexual Health Inventory for Men (SHIM) questionnaire, respectively.
- Assessments were conducted before and 6 months after CRT implantation, alongside evaluations of left ventricular ejection fraction (LVEF) and New York Heart Association (NYHA) class.
Main Results:
- CRT significantly improved NYHA class (3.4 to 2.1) and LVEF (18% to 32%) after 6 months (P<0.001 for both).
- A significant increase in SHIM scores and a decrease in AMS scores indicated improved sexual function.
- Improvements in sexual function correlated positively with increased LVEF and improved NYHA class.
Conclusions:
- Cardiac resynchronization therapy (CRT) demonstrably enhances libido and erectile function in male patients suffering from congestive heart failure (HF).
- These improvements in sexual health are directly linked to the therapy's positive effects on left ventricular ejection fraction (LVEF) and overall functional capacity.
Background:
Chronic heart failure (HF) is a common, complex clinical syndrome characterized by dyspnea, fatigue and exercise intolerance. HF patients experience decreased libido and erectile dysfunction (ED). The effects of cardiac resynchronization therapy (CRT) on libido and erectile function have not been previously evaluated. We aimed to investigate the effects of CRT on libido and ED.
Hypothesis:
Cardiac resynchronization therapy improves libido and ED.
Methods:
Thirty-one male patients with advanced HF, scheduled for implantation of a CRT device, were included in the study. Left ventricular systolic function, New York Heart Association (NYHA) class, libido, and ED were assessed before and 6 months after CRT. Libido and ED were evaluated with the Aging Male Symptoms (AMS) rating scale and internationally validated Sexual Health Inventory for Men (SHIM) questionnaire, respectively.
Results:
At the 6-month follow-up, the mean NYHA class improved from 3.4 ± 0.5 to 2.1 ± 0.6 (P<0.001). On echocardiographic examination, an improvement in left ventricular ejection fraction (LVEF) from 18 ± 5% to 32 ± 6% was detected (P<0.001). A significant increase in mean SHIM score and a significant decrease in mean AMS were noted. Changes in SHIM and AMS scores were correlated positively with the increase in LVEF (r = 0.47, P = 0.007 and r = - 0.36, P = 0.04, respectively). Similarly, SHIM scores were correlated negatively (r = - 0.57, P = 0.001) and AMS scores were correlated positively (r = 0.73, P = 0.0001) with the improvement in NYHA class.
Conclusions:
CRT results in a significant improvement in libido and erectile function in patients with congestive HF. This improvement is related to the improvements in the LVEF and functional capacity. .
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