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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Published on: March 1, 2016

Dual responsive nanostructured surfaces for biomedical applications.

Gabriela V Martins¹, João F Mano, Natália M Alves

¹3B's Research Group - Biomaterials, Biodegradables, and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806-909 Caldas das Taipas Guimarães, Portugal.

Langmuir : the ACS Journal of Surfaces and Colloids

|June 7, 2011

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We developed thermoresponsive nanostructured films using chitosan-graft-NIPAAm and alginate. These films show temperature-dependent cell sheet detachment, useful for tissue engineering applications.

Area of Science:

Materials Science
Biomaterials Engineering
Polymer Chemistry

Background:

Thermoresponsive polymers offer tunable properties for advanced applications.
Layer-by-layer assembly is a versatile technique for creating thin films.
Chitosan and alginate are biocompatible polymers with potential in biomedical fields.

Purpose of the Study:

To construct and characterize novel thermoresponsive nanostructured films.
To investigate the temperature-dependent behavior of these films for potential cell sheet engineering.
To explore the use of chitosan-graft-NIPAAm and alginate in polyelectrolyte multilayers.

Main Methods:

Synthesis of chitosan-graft-NIPAAm copolymer confirmed by FTIR and (1)H NMR.
Layer-by-layer assembly of copolymer and alginate to form polyelectrolyte multilayers.

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In situ monitoring using quartz crystal microbalance with dissipation monitoring and ex situ UV-vis measurements.

Atomic force microscopy (AFM) to analyze film morphology and thermoresponsive behavior.

Main Results:

The synthesized copolymer exhibited a lower critical solution temperature (LCST) of 31-33 °C.
Multilayer film growth was linear and influenced by salt concentration.
AFM confirmed the thermoresponsive nature of the nanostructured films, showing reconformation upon temperature changes.
Preliminary cell culture studies demonstrated temperature-induced detachment of cell sheets below the LCST.

Conclusions:

Successfully fabricated thermoresponsive nanostructured films with tunable properties.
Demonstrated the potential of these films for temperature-controlled cell sheet detachment.
Highlighted the suitability of these materials for applications in tissue engineering and regenerative medicine.