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Updated: Jun 1, 2026
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Published on: October 16, 2015
Identification of a naturally occurring quinazolin-4(3H)-one firefly luciferase inhibitor
Brinda Somanadhan1, Chungyan Leong, Stephen R Whitton
1MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II 117528, Singapore. brinda@merlionpharma.com
Abstract:
A prefractionated Streptomyces-derived extract was initially identified as being active using a luciferase-based AMP-activated protein kinase (AMPK) assay. Bioassay-guided fractionation led to the isolation of the new compound quinazolin-4(3H)-one (1) as the active component. However, 1 was shown to have potent firefly luciferase inhibitory activity with no effect on AMPK. This is the first report of a natural luciferase inhibitor.
