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Fabrication of polydimethylsiloxane (PDMS)-Based Flexible Surface-Enhanced Raman Scattering (SERS) Substrate for Ultrasensitive Detection

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Surface-enhanced Raman scattering from an etched polymer substrate.

N J Szabo¹, J D Winefordner

¹Department of Chemistry, University of Florida, P.O. Box 110702, Gainesville, Florida 32611.

Analytical Chemistry

|June 7, 2011

Summary

This study introduces etched polymer as a cost-effective substrate for Surface-Enhanced Raman Spectroscopy (SER) analysis, achieving high sensitivity and low variability for detecting various analytes.

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Area of Science:

Materials Science
Analytical Chemistry
Spectroscopy

Background:

Surface-Enhanced Raman Spectroscopy (SER) is a powerful analytical technique.
Developing robust and cost-effective substrates is crucial for routine SER analysis.
Existing substrates like crossed gratings and quartz wafers have limitations.

Purpose of the Study:

To evaluate etched poly(ethylene terephthalate) (PET) as a novel substrate for SER analysis.
To compare the performance of etched PET with traditional SER substrates.
To explore methods for enhancing SER performance on polymer substrates.

Main Methods:

Etched poly(ethylene terephthalate) (PET) sheets were prepared.
Silver nanoparticles were deposited onto PET using chemical reduction, sputtering, and vapor deposition.
The substrates were tested for SER analysis using crystal violet and other analytes.
Enhancement factors, linearity, limits of detection, and variability were measured.

Main Results:

Etched PET substrates demonstrated performance comparable to crossed gratings and quartz wafers.
Enhancement factors ranged from 10^4 to over 10^5.
Linearity up to three orders of magnitude was achieved with detection limits around 5 pg.
Variability was consistently below 20% relative standard deviation (RSD).
A thin water film enhanced SER signals beyond dry substrate capabilities.

Conclusions:

Etched polymer, specifically PET, is a viable and cost-effective substrate for routine SER analysis.
The developed method offers high sensitivity, good linearity, and low variability.
Further enhancements are possible with the addition of a liquid analyte layer.