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Related Experiment Video

Updated: Jun 1, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Extended scan depth optical coherence tomography for evaluating ocular surface shape.

Meixiao Shen1, Lele Cui, Ming Li

  • 1Department of Ophthalmology, University of Miami, Bascom Palmer Eye Institute, 1638 NW 10th Avenue, Miami, Florida 33136, USA.

Journal of Biomedical Optics
|June 7, 2011
PubMed
Summary
This summary is machine-generated.

A new method uses extended depth spectral domain optical coherence tomography (SD-OCT) for precise ocular surface shape measurement, crucial for custom contact lens fitting and noninvasive eye evaluations.

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Optical Imaging

Background:

  • Accurate ocular surface topography is essential for contact lens fitting.
  • Traditional methods may lack precision or invasiveness.
  • Extended scan depth optical coherence tomography offers potential for comprehensive ocular surface analysis.

Purpose of the Study:

  • To develop and validate a novel method for quantitative ocular surface shape measurement using a custom anterior segment SD-OCT.
  • To assess the accuracy and repeatability of this technique for applications in contact lens fitting.

Main Methods:

  • Utilized a custom-built anterior segment spectral domain optical coherence tomography (SD-OCT) with extended scan depth.
  • Implemented a crosshair alignment system to minimize eye misalignment and tilting.
  • Developed an automated algorithm for ocular surface segmentation and corrected for image distortion from a non-telecentric scanning system.

Main Results:

  • The SD-OCT method demonstrated high accuracy in measuring a bicurved test surface, with a maximum height error of 17.4 μm.
  • In vivo measurements showed good repeatability, with standard deviations for height measurements across a 14-mm range being less than 35 μm.
  • Validated the feasibility of noninvasive ocular surface shape evaluation using extended depth SD-OCT.

Conclusions:

  • The developed SD-OCT method provides accurate and repeatable quantitative measurements of the entire ocular surface shape.
  • This technique is suitable for noninvasive ocular surface evaluation and has direct applications in optimizing contact lens fitting.
  • Extended depth SD-OCT represents a significant advancement for ophthalmic diagnostics and personalized vision correction.