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Related Experiment Video

Updated: Jun 1, 2026

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

Unilateral spatial neglect in degenerative brain pathology.

Maria Caterina Silveri¹, Nicoletta Ciccarelli, Antonella Cappa

¹Medical Centre for the Ageing-Memory Clinic, Catholic University, Rome, Italy. silveri@rm.unicatt.it

Neuropsychology

|June 7, 2011

Summary

Degenerative brain diseases can cause spatial neglect by disrupting large-scale attention networks, not just individual brain areas. Different patterns of network damage lead to varied neglect syndromes, impacting spatial working memory.

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Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

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Area of Science:

Neuroscience
Cognitive Neurology

Background:

Spatial neglect is often viewed as a disconnection syndrome.
Degenerative brain diseases are system pathologies that may affect neural subsystems.

Purpose of the Study:

To investigate neglect as a disconnection syndrome in degenerative diseases.
To explore how damage to specific neural subsystems of spatial attention leads to different neglect presentations.

Main Methods:

Studied five patients with neurodegenerative diseases: corticobasal degeneration (CBD), Posterior Cortical Atrophy (PCA), and frontotemporal dementia (FTD).
Analyzed lesion patterns and resulting neglect symptoms, including allocentric, egocentric, and motor-executive neglect.

Main Results:

Corticobasal degeneration (CBD) with left parietoccipital atrophy caused right allocentric neglect.
Posterior Cortical Atrophy (PCA) in right posterior regions led to left egocentric extrapersonal neglect.
Frontotemporal dementia (FTD) with right frontotemporal atrophy resulted in left motor-executive neglect; all patients had impaired spatial working memory.

Conclusions:

Left neglect is more common than right neglect in degenerative pathologies.
Damage to distinct neural substrates underlies different types of neglect.
Findings support models of spatial attention involving both lateralized and nonlateralized attention disorders.