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Hepatic diseases in the elderly.

J Van Dam1, J B Zeldis

  • 1Brigham and Women's Hospital, Boston, Massachusetts.

Gastroenterology Clinics of North America
|June 1, 1990
PubMed
Summary

Liver disease in older adults presents subtly due to aging effects. Geriatric patients face higher risks from medications and advanced liver conditions like alcoholic liver disease.

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Area of Science:

  • Geriatric Medicine
  • Hepatology
  • Clinical Pharmacology

Background:

  • Aging impacts the liver's resilience to metabolic, infectious, and immunologic challenges.
  • Liver function tests are generally unaffected by age, but disease presentation can be altered.
  • Geriatric patients exhibit unique physiological changes influencing drug metabolism and susceptibility to liver conditions.

Purpose of the Study:

  • To outline the clinical manifestations of liver disease in the geriatric population.
  • To highlight age-related factors influencing liver disease presentation and management in the elderly.
  • To identify specific risks faced by older adults concerning liver health and pharmacotherapy.

Main Methods:

  • Review of clinical manifestations in geriatric patients with liver disease.
  • Analysis of age-related changes in liver function and drug metabolism.
  • Examination of the prevalence and severity of common liver diseases in the elderly.

Main Results:

  • Liver disease presentation in the elderly can be more subtle than in younger individuals, e.g., viral hepatitis.
  • Conditions like alcoholic liver disease and primary biliary cirrhosis are often advanced in geriatric patients.
  • Polypharmacy and altered drug metabolism in the elderly increase the risk of adverse drug reactions affecting the liver.

Conclusions:

  • Clinical presentation of liver disease in older adults is influenced by cumulative aging effects and senescence.
  • Geriatric patients require careful consideration of altered drug metabolism and potential for advanced disease.
  • Subtle presentations and increased medication risks necessitate vigilant monitoring for liver conditions in the elderly.

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