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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

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Related Experiment Video

Updated: Jun 1, 2026

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

Thyroid effects and anticancer treatment.

C Nozières1, C Damatte-Fauchery, F Borson-Chazot

  • 1Fédération d'endocrinologie du pôle Est, groupement hospitalier Est, Bron, France. cnozieres@yahoo.fr

Annales D'Endocrinologie
|June 7, 2011
PubMed
Summary
This summary is machine-generated.

Cancer therapies like radiotherapy and targeted therapies can harm the thyroid gland, leading to dysfunction years later. Endocrinologists must monitor these effects to improve patient well-being.

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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Cancer therapies, including radiotherapy, chemotherapy, and targeted therapies, can have significant consequences on thyroid function.
  • Thyroid dysfunction is a known side effect, particularly after irradiation, and is increasingly recognized with newer treatment modalities.

Purpose of the Study:

  • To review the known and emerging thyroid consequences of various cancer therapies.
  • To emphasize the importance of endocrinologists being aware of these potential late-onset endocrine effects.

Main Methods:

  • Review of existing literature on thyroid dysfunction following cancer treatments.
  • Discussion of the impact of radiotherapy, chemotherapy, and targeted therapies, including antiangiogenic drugs.

Main Results:

  • Thyroid insufficiency and cancer are known risks following cervical or total body irradiation.
  • Thyroid dysfunction, often occurring late (months to years post-treatment), is a well-established effect of antiangiogenic drugs.

Conclusions:

  • Improved cancer survival necessitates greater awareness of treatment-related endocrine side effects.
  • Endocrinologists play a crucial role in the adequate survey and management of thyroid dysfunction to enhance patient well-being.