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Factors influencing precipitation of pH-adjusted bupivacaine solutions
P Bourget1, L Bonhomme, D Benhamou
1Department of Anesthesiology, University of Paris-Sud, Hospital Antoine Beclere, Clamart, France.
Journal of Clinical Pharmacy and Therapeutics
|June 1, 1990
Abstract:
Solutions of bupivacaine precipitate when bicarbonate is added. This limits the clinical use of pH-adjustment in optimizing bupivacaine activity. In this study four different bupivacaine solutions were studied with the addition of sodium bicarbonate at 4 degrees C or 20 degrees C. Bupivacaine concentrations remained unchanged after pH-adjustment. Least crystallization was observed with bupivacaine solutions containing a small amount of sodium bicarbonate and stored at 4 degrees C.