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Histopathological development of equine cutaneous papillomas
M Hamada1, T Oyamada, H Yoshikawa
1Department of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Journal of Comparative Pathology
|May 1, 1990
Summary
Equine cutaneous papillomas develop through distinct growth, development, and regression phases. Histopathology reveals basal cell hyperplasia and intranuclear inclusion bodies (IIB) associated with papillomavirus infection in horses.
Area of Science:
- Veterinary Pathology
- Equine Dermatology
- Viral Oncology
Background:
- Equine cutaneous papillomas are common skin tumors in horses.
- Understanding their histopathological progression is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the histopathological development of equine cutaneous papillomas.
- To characterize lesions during natural and experimentally induced infections.
Main Methods:
- Histopathological examination of naturally occurring and experimentally induced equine warts.
- Categorization of lesions into growth, development, and regression phases.
- Immunohistochemical detection of bovine papillomavirus antigens using anti-bovine papillomavirus serum.
Main Results:
- Growing phase: basal cell hyperplasia, acanthosis, hyper-/parakeratosis, and few intranuclear inclusion bodies (IIB).
- Developing phase: prominent acanthosis, cellular changes, numerous IIB in prickle/granular cells.
- Regressing phase: near-normal epidermis, rete peg proliferation, dermal fibroblast/collagen increase.
- Novel fibropapilloma description in 10 spontaneous and 1 experimental equine wart.
Conclusions:
- Papillomas initiate with basal cell hyperplasia, followed by acanthosis, hyper-/parakeratosis, and IIB production.
- Intranuclear inclusion bodies (IIB) are key indicators of papillomavirus presence.
- Fibropapillomas represent a previously undescribed variant in horses.