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High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
Published on: November 10, 2015
Multi-decade hippocampal and amygdala volume analysis: equal variability and limited age effect
Abderazzak Mouiha1, Simon Duchesne
1Centre de Recherche Université Laval Robert-Giffard, Québec, Canada.
Neuroscience Letters
|June 7, 2011
Summary
Hippocampal (HC) and amygdala (AG) volumes show minimal age-related changes in adults. This study provides normative data for HC/AG volumes across age and sex, challenging assumptions about neurodegeneration.
Area of Science:
- Neuroscience
- Brain Imaging
- Aging Research
Background:
- Hippocampal (HC) and amygdala (AG) volume variability in asymptomatic adults is not well-characterized.
- Existing research presents conflicting findings on age-related changes in HC/AG volumes.
Purpose of the Study:
- To precisely investigate the effects of age, sex, and hemisphere on HC/AG volumes throughout adulthood.
- To establish normative data for HC/AG volumes across different age groups and sexes.
Main Methods:
- Manual segmentation of HC and AG volumes in 422 subjects (aged 20-84).
- Hierarchical regression analysis to assess age, sex, and hemisphere effects.
- ANOVA to compare volume variability across age strata.
Main Results:
- HC and AG volumes were not significantly related to age or age squared, except for the right AG.
- No significant differences in volume variability were found across age strata.
- The right amygdala showed a significant relationship with age.
Conclusions:
- HC/AG volumes exhibit stable variability throughout asymptomatic adulthood, challenging typical neurodegeneration models.
- The findings provide valuable normative data for HC/AG volumes, aiding future clinical and fundamental research.
