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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Cancer immunotherapy

Richard L White1, Asim Amin

  • 1Division of Surgical Oncology, Carolinas Medical Center, Blumenthal Cancer Center, 1025 Morehead Medical Drive, Suite 600, Charlotte, NC 28204, USA. Richard.White@carolinashealthcare.org

Surgical Oncology Clinics of North America
|June 7, 2011
PubMed

Immune-based therapies for cancer are now commonplace. Cytokine therapy, including interferon and interleukin-2, is safe in the community setting. The US Food and Drug Administration has recently approved sipuleucel-T for the treatment of advanced prostate cancer, the first therapeutic cancer vaccine to meet this level of efficacy. The therapeutic use of monoclonal antibodies directed against proteins controlling various cell functions, including growth and modulation of immune response, has become so pervasive that the oncologist, whether surgeon or medical oncologist, must be familiar with indications, contraindications, and the associated toxicities.

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