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Updated: Jun 1, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
Renal nerves, WNK4, glucocorticoids, and salt transport
David H Ellison1, Virginia L Brooks
1Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239, USA. ellisond@ohsu.edu
Abstract:
Roles of the sympathetic nervous system versus kidney salt transporters in hypertension are debated. A study in Nature Medicine (Mu et al., 2011) shows that dietary salt excess, coupled with β-adrenergic stimulation, increases arterial pressure via glucocorticoid receptors and WNK4, suggesting interactions between these systems in the pathogenesis of hypertension.
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