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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

[Hypertensive nephrosclerosis].

Thierry Krummel¹, Dorothée Bazin, Anne-Laure Faller

¹Hôpitaux universitaires de Strasbourg, faculté de médecine de Strasbourg, service de néphrologie, 67091 Strasbourg cedex, France. thierry.krummel@chru-strasbourg.fr

Presse Medicale (Paris, France : 1983)

|June 7, 2011

Summary

This summary is machine-generated.

Hypertensive nephrosclerosis, a leading cause of kidney failure, presents with non-specific vascular damage. Genetic factors like MYH9/APOL1 variants may play a role, necessitating tailored blood pressure targets for effective management.

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

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Published on: October 26, 2020

Area of Science:

Nephrology and Hypertension Research
Renal Pathology and Genetics
Cardiovascular Epidemiology

Context:

Hypertensive nephrosclerosis is the primary cause of end-stage renal disease (ESRD) in France.
ESRD incidence in hypertension trials is low (0.2-0.4% annually), contrasting with its leading role in ESRD.
Histological features are non-specific, overlapping with aging and obesity, complicating diagnosis.

Purpose:

To review the characteristics, diagnosis, and treatment of hypertensive nephrosclerosis.
To highlight the association with genetic variants (MYH9/APOL1) and their unclear pathophysiology.
To discuss current treatment strategies, including renin-angiotensin system blockade and target blood pressure.

Summary:

Hypertensive nephrosclerosis exhibits non-specific vascular changes and carries a poor prognosis due to cardiovascular and renal burden.
Differential diagnoses include atherosclerotic ischemic renal disease and primitive nephropathies.
Genetic predisposition, particularly MYH9/APOL1 variants in individuals of African ancestry, is strongly implicated but not fully understood.

Impact:

Improved understanding of hypertensive nephrosclerosis, aiding in differential diagnosis and risk assessment.
Highlights the potential role of genetic factors in disease development.
Informs treatment guidelines, emphasizing renin-angiotensin system blockade and lower blood pressure targets (<130/80 mmHg) for patients with proteinuria.