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Enhancing cervical cancer detection using nucleic acid hybridization and acetic acid tests
G Ficsor1, S K Fuller, J L Jeromin
1Western Michigan University, Kalamazoo.
The Nurse Practitioner
|July 1, 1990
Summary
Acetowhitening and human papillomavirus (HPV) tests can identify women at increased risk for cervical cancer, complementing the Papanicolaou (Pap) test. These methods detect cases missed by the Pap test alone, improving early risk assessment.
Area of Science:
- Gynecology
- Oncology
- Virology
Background:
- Acetowhitening of cervical epithelium is a potential indicator of increased cervical cancer risk.
- Certain human papillomavirus (HPV) types (16, 18, 31, 33, 35) are associated with elevated cervical cancer risk.
Purpose of the Study:
- To evaluate if acetowhitening and HPV testing augment the Papanicolaou (Pap) smear in predicting cervical cancer risk.
- To identify women at risk for cervical cancer who might be missed by Pap testing alone.
Main Methods:
- A cohort of 145 women (ages 14-47) underwent acetowhitening (4% acetic acid), Pap testing, and HPV testing (ViraPap and ViraType).
- Statistical analysis was used to correlate results from the different tests.
Main Results:
- 30 women (20.6%) showed acetowhitening, 14 (9.6%) had a positive Pap test, and 13 (9%) tested positive for HPV.
- A positive correlation was observed between Pap, ViraPap, and acetic acid tests.
- Acetowhitening and HPV tests alone identified 14.5% and 6.2% of women at risk, respectively.
- Four women with negative Pap tests were infected with high-risk HPV types.
Conclusions:
- Acetowhitening and HPV tests are valuable adjuncts to the Pap test for cervical cancer risk assessment.
- These tests can detect women at risk who may not be identified by the Pap test alone.
- Integrating these methods enhances the comprehensive screening for cervical cancer risk.