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Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice
Published on: September 17, 2015
Tea catechins prevent contractile dysfunction in unloaded murine soleus muscle: a pilot study.
Noriyasu Ota1, Satoko Soga, Satoshi Haramizu
1Biological Science Laboratories, Kao Corporation, Tochigi, Japan. ota.noriyasu@kao.co.jp
Nutrition (Burbank, Los Angeles County, Calif.)
|June 7, 2011
Summary
Green tea catechins supplementation reduced muscle dysfunction and atrophy caused by unloading. This dietary intervention protected skeletal muscle by reducing oxidative stress and preserving muscle force.
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
- Skeletal Muscle Research
Background:
- Muscle disuse, inactivity, and bed rest lead to muscle atrophy and reduced force.
- Oxidative stress increases during periods of muscle unloading.
- Green tea catechins possess antioxidant properties.
Purpose of the Study:
- To investigate the effects of green tea catechins on muscle dysfunction induced by unloading.
- To assess the impact of catechins on muscle mass, force, and oxidative stress markers.
Main Methods:
- Male mice were fed control or green tea catechin-supplemented diets.
- Mice underwent 10 days of hind limb unloading via tail suspension.
- Muscle weight, contractile force, antioxidant potential, and protein carbonylation were measured.
Main Results:
- Tail suspension decreased soleus muscle weight and force.
- Catechin intake preserved muscle force by 19% and prevented force decline.
- Catechins suppressed the reduction in antioxidant potential and increased protein carbonylation.
Conclusions:
- Green tea catechin ingestion mitigates skeletal muscle contractile dysfunction and atrophy during unloading.
- The antioxidant activity of catechins likely contributes to protecting myofibrillar proteins from oxidative damage.
