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Updated: Jun 1, 2026
10:46
A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates.
In-Hyun Lee1, Sukyung An, Mi Kyung Yu
1Cell Dynamics Research Center, School of Life Sciences, Gwang ju Institute of Science and Technology, Buk-gu, Gwang ju, Republic of Korea.
Summary
Researchers developed a novel nano-platform for targeted chemoimmunotherapy, improving drug delivery for prostate cancer treatment. This innovative system, utilizing a dendrimer and RNA aptamer hybrid, shows promise in preclinical models.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Chemoimmunotherapy is a key area in oncological research.
- Current chemoimmunotherapy systems face challenges for clinical application.
Purpose of the Study:
- To establish a novel nano-platform for effective chemoimmunotherapy.
- To overcome limitations of conventional cancer therapies.
Main Methods:
- Developed a drug-delivery system using a dendrimer and a single-strand DNA-A9 prostate-specific membrane antigen (PSMA) RNA aptamer hybrid.
- Tested the system in in vitro and in vivo models.
Main Results:
- Demonstrated a promising chemoimmuno therapeutic system.
- Showcased the potential of the nano-platform for targeted drug delivery.
Conclusions:
- The novel nano-platform offers a potential solution for efficient chemoimmunotherapy.
- The developed system shows efficacy against prostate cancer in preclinical studies.
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