[Kininase II (SACE) and renin in sarcoidosis patients and healthy probands in exercise testing]

Over a period of three years, we investigated the behaviour of renin and kininase II in 26 patients with active, histologically confirmed sarcoidosis in comparison with healthy test subjects, during ergometer exercise. Renin activity was determined radioimmunologically, and kininase II by means of spectral photometry (Cushman-Lieberman method). In both groups, a significant increase in renin and kininase II during the course of exercise on the ergometer was observed, which, however, was more marked in the sarcoidosis group of patients. Furthermore, the activities of both enzymes were highly significantly elevated as compared with the group of healthy subjects in each individual phase of exercise. In addition--if we consider the average values of the two enzymes in each of the individual subjects--it would seem possible in most cases to correctly ascribe the person involved to the group healthy subjects or patients, in particular when the average values of renin and kininase II obtained as described above, are multiplied together.