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Updated: Jun 1, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Contrast echocardiography: contribution to diagnosis of left ventricular non-compaction cardiomyopathy
Konstantinos M Lampropoulos1, Vasilios G Dounis, Constantina Aggeli
1First Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece. klabropoulos@mycosmos.gr
Insights
Left ventricular non-compaction (LVNC) diagnosis can be challenging. Contrast echocardiography aids in accurate LVNC identification, improving patient outcomes.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Left ventricular non-compaction (LVNC) is a rare cardiomyopathy resulting from abnormal embryonic development of the heart's inner lining.
- Accurate diagnosis of LVNC is often delayed due to its resemblance to other cardiac conditions and limited physician awareness.
Observation:
- Two asymptomatic young men initially misdiagnosed with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy, respectively, were correctly identified as having LVNC through echocardiography.
- Contrast echocardiography proved crucial in distinguishing non-compacted from compacted myocardium and measuring the LVNC ratio.
Findings:
- Contrast echocardiography demonstrates high accuracy, reliability, and repeatability in diagnosing LVNC.
- This non-invasive imaging technique offers real-time assessment without ionizing radiation, making it a valuable diagnostic tool.
Implications:
- Increased clinical suspicion for LVNC is vital for timely and accurate diagnosis.
- Contrast echocardiography can significantly improve the diagnostic process for LVNC, potentially leading to earlier intervention and better management of affected individuals.
Abstract:
Left ventricular non-compaction (LVNC) is a cardiomyopathy considered to be caused by arrest of normal embryogenesis of the endocardium and myocardium. Echocardiography has been the preferred diagnostic procedure; however, the correct diagnosis is often missed or delayed due to the lack of knowledge about this uncommon disease and its similarities to other diseases of the myocardium and endocardium. Here we present two cases: an asymptomatic 39-year-old man who was considered to be suffering from dilated cardiomyopathy (DCM) for four years; and an asymptomatic 19-year-old man who was considered to be suffering from hypertrophic cardiomyopathy. In a recent echocardiography study carried out in our echo lab, we recognized the morphological diagnostic criteria of LVNC. Contrast echocardiography, a low-cost, easy, repeatable, real-time, and non-invasive technique with no ionising radiation, shows a high correlation in the diagnosis of LVNC. In echocardiography, the importance of contrast agents is twofold, as they can be considered essential for a reliable differentiation between the compacted and the non-compacted myocardium, while at the same time they allow accurate measurement of the ratio. Heightened clinical suspicion is necessary for the accurate diagnosis and management of diseases.
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