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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

[Simple coagulation prophylaxis using low-molecular heparin enoxaparin in pediatric hemodialysis]

M G Bianchetti1, S Speck, R Müller

  • 1Abteilung für Nephrologie, Medizinische Universitätskinderklinik, Bern.

Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
|June 5, 1990
PubMed

Insights

Low molecular weight heparin, enoxaparin, effectively prevents clotting in pediatric hemodialysis patients. This anticoagulation method showed excellent tolerance and no bleeding complications in children with end-stage renal failure.

Area of Science:

  • Pharmacology
  • Nephrology
  • Pediatrics

Context:

  • Extracorporeal circulation in hemodialysis requires effective anticoagulation.
  • Low molecular weight heparins (LMWHs) are used for anticoagulation in adults undergoing hemodialysis.
  • Limited data exists on LMWH use in pediatric hemodialysis.

Purpose:

  • To evaluate the efficacy and safety of enoxaparin for anticoagulation in pediatric hemodialysis.
  • To determine appropriate dosing for enoxaparin in children undergoing hemodialysis.

Summary:

  • Seven pediatric patients (7-18 years) with end-stage renal failure received an initial bolus of enoxaparin (24-36 mg/m2) for hemodialysis.
  • Enoxaparin provided effective anticoagulation for at least four hours.
  • No hemorrhage or adverse events were reported, indicating excellent tolerance.

Impact:

  • Enoxaparin is a safe and effective anticoagulation option for pediatric hemodialysis.
  • This study supports the use of enoxaparin in children requiring extracorporeal circulation.
  • Establishes a basis for further research into LMWH anticoagulation in pediatric nephrology.

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