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Generation of fertile sperm in a culture dish: clinical implications

Hoi-Hung Cheung1, Owen M Rennert

  • 1Section on Clinical and Developmental Genomics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, Bethesda, MD 20892, USA.

Asian Journal of Andrology
|June 7, 2011
PubMed
Abstract

No abstract available in PubMed .

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...