[Thermal sensitivity of enzymes in trisomy 21 leukocytes]

Thermosensitivity of glucose 6-phosphate dehydrogenase and myloperoxidase was investigated in the leukocyte lysates from patients with Down's syndrome. A statistically significant enhancement of thermosensitivity of both the enzymes investigated was revealed in the aberrant cells in comparison with the control. The noted differences can be based on the increased incidence of mutation injuries in the aberrant cells, as well as on anomalous postranslational modification of the protein molecules.