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Updated: Jun 1, 2026

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Characterization of Tunable Radical Metal-Carbenes: Key Intermediates in Catalytic Cyclopropanation
Jonathan L Belof1, Christian R Cioce, Xue Xu
1Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620-5250.
Abstract:
A new class of radical metal-carbene complex has been characterized as having Fischer-like orbital interactions and adjacent π acceptor stabilization. Density Functional Theory (DFT) along with Natural Bond Orbital (NBO) analysis and Charge Decomposition Analysis (CDA) has given insight into the electronics of this catalytic intermediate in an open-shell cobalt-porphyrin, [Co(Por)], system. The complex has a single bond from the metal to the carbene and has radical character with localized spin density on the carbene carbon. In addition, the carbene carbon is found to be nucleophilic and "tunable" through the introduction of different α-carbon substituents. Finally, based on these findings, rational design strategies are proposed which should lead to the enhancement of catalytic activity.
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