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Updated: Jun 1, 2026

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Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Unexpected phosphodiesterase activity at low pH of a dinuclear copper-β-cyclodextrin complex
Meng Zhao1, Han-Lu Wang, Li Zhang
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Abstract:
A surprisingly low pK(a) (4.3) for a Cu(II) bridging water was found in the presented complex, Cu(2)L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn(2)L at typical lysosomal pH (~5.0).
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