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Updated: Jun 1, 2026

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
Carcinoma cuniculatum arising in the tongue
Selvam Thavaraj1, Alistair Cobb, Nicholas Kalavrezos
1Oral Pathology, Department of Clinical and Diagnostic Sciences, King's College London Dental Institute, Floor 28 Tower Wing, Great Maze Pond, London, SE1 9RT, UK. selvam.thavaraj@kcl.ac.uk
Abstract:
Carcinoma cuniculatum (CC) is a rare, distinct clinico-pathological variant of squamous cell carcinoma (SCC) that is defined histologically by the characteristic infiltrative pattern of a deep, broad, and complex proliferation of stratified squamous epithelium with keratin cores and keratin-filled crypts. Herein, we present a case report of CC of the oral tongue and discuss its diagnosis, management, and outcome, as well as briefly review the world literature. To our knowledge, this is the first documented case of CC of the tongue to be reported in the English literature. We draw attention to its clinico-pathological features and highlight that awareness of this entity as a distinct variant of SCC facilitates its correct management.
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