Gold nanomaterials as a new tool for bioanalytical applications of laser desorption ionization mass spectrometry

Nanomaterials have emerging importance in laser desorption ionization mass spectrometry (LDI-MS) with the ultimate objective being to overcome some of the most important limitations intrinsically related to the use of conventional organic matrices in matrix-assisted (MA) LDI-MS. This review provides a critical overview of the most recent literature on the use of gold nanomaterials as non-conventional desorption ionization promoters in LDI-MS, with particular emphasis on bioanalytical applications. Old seminal papers will also be discussed to provide a timeline of the most significant achievements in the field. Future prospects and research needs are also briefly discussed.