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Possible heart failure associated with pregabalin use: case report
Gülay Erdoğan1, Dilek Ceyhan, Sacit Güleç
1Department of Anaesthesiology and Reanimation, İnönü University Faculty of Medicine, Malatya, Turkey. drgulayer@yahoo.com
Summary
Pregabalin and gabapentin, used for pain and seizures, can cause serious edema and heart issues. Caution is advised for all patients, not just those with heart conditions.
Area of Science:
- Pharmacology
- Cardiology
Background:
- Pregabalin and gabapentin are common analgesics, anticonvulsants, and anxiolytics.
- Common side effects include dizziness, somnolence, edema, and weight gain.
Observation:
- A patient without cardiac history developed edema after pregabalin treatment.
- Edema recurred with gabapentin, suggesting a drug-related effect.
- The New York Heart Association warns of pregabalin use in heart failure patients.
Findings:
- Pregabalin and gabapentin may cause peripheral and central edema.
- Potential calcium channel interactions may underlie these adverse effects.
- Case suggests these drugs pose risks beyond patients with pre-existing cardiac conditions.
Implications:
- Clinicians should exercise caution when prescribing pregabalin and gabapentin.
- Further research is needed to elucidate the mechanisms of these side effects.
- Patient monitoring for edema and cardiac symptoms is crucial during treatment.
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