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Pregnane and pregnane tetraglycoside from Marsdenia roylei
Versha Gupta1, Alok Kumar, Anakshi Khare
1Department of Chemistry, Lucknow University, Lucknow 226007, India.
Natural Product Research
|June 7, 2011
Summary
Two pregnane compounds, roylinine and marsgenin, were isolated from Marsdenia roylei stem. Their chemical structures were elucidated using advanced spectroscopic and chemical methods.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Marsdenia roylei possesses diverse bioactive compounds.
- Isolation and structural elucidation of novel natural products are crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize chemical constituents from Marsdenia roylei stem.
- To identify and determine the structures of pregnane oligoglycosides and derivatives.
Main Methods:
- Extraction of dried stem of Marsdenia roylei using chloroform.
- Structure determination using Nuclear Magnetic Resonance (NMR) spectroscopy (¹H-NMR, ¹³C-NMR, ¹H-¹H COSY, HSQC, TOCSY) and Fast Atom Bombardment Mass Spectrometry (FABMS).
- Chemical degradation and derivatisation for structural confirmation.
Main Results:
- Isolation of a pregnane oligoglycoside, roylinine.
- Isolation of a pregnane derivative, marsgenin.
- Complete structural elucidation of both compounds using comprehensive spectral and chemical analyses.
Conclusions:
- Roylinine and marsgenin are novel chemical entities isolated from Marsdenia roylei.
- The study expands the knowledge of chemical diversity within the Marsdenia genus.
- These findings contribute to the understanding of pregnane-type natural products.
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