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Updated: Jun 1, 2026

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens

Published on: April 17, 2026

Does CSF composition predict shunt malfunction in tuberculous meningitis?

S Ambekar¹, S Dwarakanath, B A Chandramouli

¹Department of Neurosurgery, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore

The Indian Journal of Tuberculosis

|June 8, 2011

Summary

This summary is machine-generated.

Elevated cerebrospinal fluid (CSF) protein levels significantly increase the risk of shunt malfunction in tuberculous meningitis (TBM) patients. Monitoring high-protein CSF is crucial for preventing complications in TBM hydrocephalus management.

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Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens

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Published on: April 17, 2026

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

Published on: October 14, 2022

Area of Science:

Neurosurgery
Infectious Diseases
Neurology

Background:

Hydrocephalus secondary to tuberculous meningitis (TBM) presents significant treatment challenges, particularly in developing nations.
Ventriculo-peritoneal shunts in TBM patients experience higher complication rates compared to other causes.

Purpose of the Study:

To investigate the association between cerebrospinal fluid (CSF) composition and shunt malfunction in TBM patients.
To identify specific CSF markers predictive of shunt failure.

Main Methods:

A comparative study analyzing CSF composition.
53 TBM patients with shunt malfunction were compared against 137 matched controls.

Main Results:

Significantly higher CSF protein concentrations were observed in patients with shunt malfunction.
CSF cellularity and glucose levels did not predict shunt malfunction.
A CSF protein concentration >200 mg/dL correlated with a fourfold increased risk of shunt malfunction.

Conclusions:

Elevated CSF protein concentration (>200 mg/dL) is a significant risk factor for shunt malfunction in TBM.
Close patient follow-up is recommended for those with high CSF protein levels.
CSF protein levels are a key indicator for shunt complication risk in TBM hydrocephalus.