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Updated: Jun 1, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Conversion of α-amino acids into bioactive o-aminoalkyl resorcylates and related dihydroxyisoindolinones
Bhavesh H Patel1, Andrew M Mason, Hetal Patel
1Department of Chemistry, Imperial College, London SW7 2AZ, England.
Abstract:
The synthesis of biologically active o-aminoalkyl resorcylates and related dihydroxyisoindolinones from functionalized α-amino acids without the use of phenolic protection is described. The key aminoalkyl-diketo-dioxinone intermediates were prepared utilizing a crossed Claisen condensation reaction in the presence of diethylzinc. The aromatic unit was constructed via late stage cyclization and aromatization, and subsequent modification provided the novel resorcylates which showed activity against a selection of receptors and kinases, including 5-HT and CDK.
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