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Related Experiment Video

Updated: Jun 1, 2026

Sample Drift Correction Following 4D Confocal Time-lapse Imaging

Sample Drift Correction Following 4D Confocal Time-lapse Imaging

Published on: April 12, 2014

A drift correction procedure.

M L Salit¹, G C Turk

¹Chemical Science and Technology Laboratory, Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8391.

Analytical Chemistry

|June 8, 2011

Summary

This study introduces a new procedure to reduce low-frequency noise, or drift, in analytical experiments. Repeatedly measuring samples improves precision and data accuracy over long periods.

Area of Science:

Analytical Chemistry
Instrumental Analysis

Background:

Low-frequency noise, termed drift, negatively impacts analytical experiment precision.
Traditional methods rely on periodic standard measurements to correct for instrument response variations.

Purpose of the Study:

To introduce a novel procedure for mitigating drift in analytical experiments.
To enhance the precision and data integrity of analytical measurements over extended durations.

Main Methods:

Utilizing repeated sample measurements as a drift diagnostic tool.
Developing a model to diagnose instrument response drift from repeated measurements.
Correcting data to a drift-free condition for improved accuracy.

Main Results:

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Achieved over 10-fold precision enhancements in analytical atomic emission results.

Demonstrated no statistically significant effects on the means of the results.

Enabled data accumulation over long periods with minimal precision loss due to drift.

Conclusions:

The new procedure effectively mitigates drift, significantly improving analytical precision.
Repeated sample measurements offer a superior approach to drift correction compared to traditional methods.
This method allows for reliable long-term data collection in analytical experiments.