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Capillary Electrophoresis: Instrumentation

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Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...

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Related Experiment Video

Updated: Jun 1, 2026

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System

Published on: November 21, 2023

Contactless conductivity detection for capillary electrophoresis.

A J Zemann¹, E Schnell, D Volgger

¹Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens-University Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria.

Analytical Chemistry

|June 8, 2011

Summary

A novel contactless conductivity detector for capillary electrophoresis was developed. This device offers a detection limit of 200 ppb for inorganic ions, enhancing analytical capabilities.

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Last Updated: Jun 1, 2026

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System

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Published on: November 21, 2023

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Published on: February 16, 2018

Area of Science:

Analytical Chemistry
Separation Science

Background:

Capillary electrophoresis (CE) requires sensitive detection methods.
Existing conductivity detectors can be complex or invasive.

Purpose of the Study:

To introduce a new contactless capacitively coupled conductivity detector for CE.
To demonstrate its performance for detecting inorganic ions.

Main Methods:

A detector with cylindrical electrodes around a fused-silica capillary was designed.
High audio or low ultrasonic frequencies were used to minimize reactance.
An improved version utilized syringe cannulas for easy detector placement.

Main Results:

The detector successfully measured the electric conductivity of solutions within the capillary.
A limit of detection of 200 ppb was achieved for sodium and chloride ions.
The syringe cannula design allowed for flexible positioning along the capillary.

Conclusions:

The contactless capacitively coupled conductivity detector is a viable and sensitive tool for CE.
Its design offers advantages in ease of use and adaptability.
This detector advances the field of capillary electrophoresis analysis.