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Related Experiment Videos

Human suppressor T cell clones lack CD28.

S G Li1, T H Ottenhoff, P Van den Elsen

  • 1Department of Immunohaematology and Blood Bank, University Hospital, Leiden, The Netherlands.

European Journal of Immunology
|June 1, 1990
PubMed
Summary
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Leprosy patients have T helper (Th) cells that support immune responses and T suppressor (Ts) cells that inhibit them. Ts cells can kill target cells, but this is separate from their suppressive function, with CD28 marking Th cells but not Ts cells.

Area of Science:

  • Immunology
  • Cellular Biology
  • Mycobacterial Infections

Background:

  • Lepromatous leprosy involves T cell dysfunction.
  • Previously identified T cell clones (Th) proliferate to Mycobacterium leprae (M. leprae), while others (Ts) suppress autologous T cell proliferation.
  • Ts clones are CD4+ and proliferate less vigorously to M. leprae than Th cells.

Purpose of the Study:

  • Investigate the mechanism of antigen-specific T cell suppression.
  • Identify phenotypic differences between T helper (Th) and T suppressor (Ts) clones.

Main Methods:

  • Functional assays to assess T cell proliferation and cytotoxicity.
  • Phenotypic analysis of T cell clones using markers like CD4, CD28.
  • Antigen presentation studies using Mycobacterium leprae (M. leprae) and autologous cells.

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Main Results:

  • T suppressor (Ts) clones possess cytotoxic capabilities.
  • Suppression and cytotoxicity mediated by Ts clones against M. leprae could be dissociated.
  • T helper (Th) clones express the CD28 marker, while T suppressor (Ts) clones do not.

Conclusions:

  • T suppressor (Ts) cells have a lytic mechanism distinct from their suppressive function.
  • The CD28 marker is a key phenotypic differentiator between M. leprae-specific Th and Ts cells.