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Updated: Jun 1, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
The in vitro diagnosis of drug allergy: status and perspectives
1Faculty of Medicine, Department of Immunology, Allergology and Rheumatology, University Antwerp, Antwerpen, Belgium. immuno@ua.ac.be
Abstract:
Adverse drug reactions (ADR) can result from immune-mediated (drug allergy) and nonimmune-mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T-cell mediated) drug allergy, particularly quantification of specific IgE, flow-assisted analysis of in vitro activated lymphocytes and basophils and the enzyme-linked immunosorbent spot.
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