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Measurement properties of translated versions of neck-specific questionnaires: a systematic review

Jasper M Schellingerhout1, Martijn W Heymans, Arianne P Verhagen

  • 1Department of General Practice, Erasmus Medical Centre, Rotterdam, The Netherlands. j.schellingerhout@erasmusmc.nl

Abstract

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Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...