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Related Concept Videos

Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Related Experiment Video

Updated: Jun 1, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Community-based knowledge translation: unexplored opportunities.

Anita Kothari1, Rebecca Armstrong

  • 1Faculty of Health Sciences, and Schulich School of Medicine and Dentistry, University of Western Ontario, Health Sciences Building 222, London, Ontario, Canada, N6A 5B9. akothari@uwo.ca

Implementation Science : IS
|June 8, 2011
PubMed
Summary
This summary is machine-generated.

Community-based organizations require tailored knowledge translation (KT) approaches that value collaboration, context-specific evidence, and advocacy. Current KT frameworks often overlook these unique needs, hindering effective knowledge exchange in community settings.

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Published on: May 9, 2017

Area of Science:

  • Health Services Research
  • Community Health
  • Knowledge Translation Studies

Background:

  • Knowledge translation (KT) is an interactive process of knowledge exchange between health researchers and users.
  • Current KT approaches may not adequately address the unique characteristics of community-based organizations (CBOs).
  • Settings and focus significantly influence KT definitions and applications.

Purpose of the Study:

  • To highlight the distinctive challenges and perspectives of CBOs in the knowledge translation process.
  • To stimulate discussion on adapting KT for community-based settings.
  • To identify areas for improvement in current KT frameworks and tools for CBOs.

Main Methods:

  • This study is a commentary based on experience with community-based organizations.
  • It involves reflection on the scope and application of KT in diverse health system settings.
  • It identifies common characteristics of CBOs and their implications for KT.

Main Results:

  • CBOs prioritize collaborative processes with multi-sector stakeholders.
  • 'Evidence' in CBO settings is conceptualized broadly, including context-specific and tacit knowledge alongside research findings.
  • CBOs desire local information and engage in advocacy, functions often ignored by traditional KT.

Conclusions:

  • KT approaches must be adapted to accommodate the unique needs and values of CBOs, including collaboration, context-specific evidence, and advocacy.
  • Developing processes to help CBOs adapt research findings to local contexts is crucial for advancing decision-making.
  • Further research is needed to explore and evaluate alternative KT strategies within community-based settings.