Related Experiment Video
Updated: Jun 1, 2026
05:04
Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
Published on: November 19, 2020
Five-year clinical and angiographic outcomes of a randomized comparison of sirolimus-eluting and paclitaxel-eluting
Lorenz Räber1, Lea Wohlwend, Mathias Wigger
1Department of Cardiology, Bern University Hospital, 3010 Bern, Switzerland.
Circulation
|June 8, 2011
Summary
Long-term data show sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) have similar 5-year clinical and angiographic outcomes. Incomplete vascular healing and very late stent thrombosis risk persist up to 5 years for these first-generation drug-eluting stents.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomaterials Science
Background:
- Limited long-term comparative data exist for first-generation drug-eluting stents.
- This study evaluates 5-year outcomes of sirolimus-eluting stents (SES) versus paclitaxel-eluting stents (PES).
Purpose of the Study:
- To compare the 5-year clinical and angiographic outcomes of SES and PES.
- To assess long-term vascular healing and stent thrombosis rates.
Main Methods:
- The SIRTAX LATE study randomized 1012 patients to SES or PES.
- Follow-up included clinical assessment and repeat angiography at 5 years in 43.8% of patients.
Main Results:
- No significant differences in major adverse cardiac events (19.7% SES vs. 21.4% PES), cardiac death, myocardial infarction, or target lesion revascularization were observed at 5 years.
- Annual rates of target lesion revascularization between years 1 and 5 were 2.0% for SES and 1.4% for PES.
- Definite stent thrombosis occurred in 4.6% of SES and 4.1% of PES, with very late stent thrombosis at an annual rate of 0.65%.
Conclusions:
- First-generation SES and PES demonstrate comparable long-term clinical and angiographic performance.
- Incomplete vascular healing and sustained risk of very late stent thrombosis are evident up to 5 years post-implantation.