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Updated: Jun 1, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
Published on: October 6, 2023
Illness-induced changes in thyroid hormone metabolism: focus on the tissue level
J Kwakkel1, E Fliers, A Boelen
1Department of Endocrinology & Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands. g.j.kwakkel@amc.uva.nl
Abstract:
During illness changes in thyroid hormone metabolism occur, collectively known as the non-thyroidal illness syndrome (NTIS). NTIS is characterised by low serum thyroid hormone levels without the expected rise in serum thyroid-stimulating hormone, indicating a major change in thyroid hormone feedback regulation. Recent studies have made clear that during NTIS differential changes in thyroid hormone metabolism occur in various tissues, the net effect of which may be either activation or inhibition of thyroid hormone action. In this review we discuss systemic and local changes in thyroid hormone metabolism during illness, highlighting their physiological implications in terms of disease course.
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