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Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples

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A highly phase-stable differential detector amplifier for magnetic induction tomography.

S Watson¹, H C Wee, H Griffiths

¹Faculty of Advanced Technology, University of Glamorgan, Pontypridd, UK. swatson1@glam.ac.uk

Physiological Measurement

|June 8, 2011

Summary

A new ultra-phase-stable, low-noise amplifier was developed for magnetic induction tomography (MIT) to improve detection of brain conditions like stroke. This amplifier shows high phase stability across temperature changes, crucial for biomedical applications.

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Area of Science:

Biomedical Engineering
Medical Imaging
Electronics Engineering

Background:

Magnetic induction tomography (MIT) shows promise for detecting cerebral edema and hemorrhagic stroke.
High phase measurement precision is a significant technical hurdle for MIT in these applications.
The detector amplifier is a critical component influencing MIT system performance.

Purpose of the Study:

To develop an ultra-phase-stable, low-noise instrumentation amplifier for MIT systems.
To evaluate the phase stability, phase noise, and drift performance of the developed amplifier.

Main Methods:

Design and simulation of an ultra-phase-stable, low-noise instrumentation amplifier.
Experimental measurement of amplifier phase stability across a temperature range (35-50 °C).
Assessment of phase noise and drift performance within a single-channel magnetic induction spectroscopy system.

Main Results:

The amplifier demonstrated exceptional phase stability, with an average change of -0.1 ± 0.6 m° °C⁻¹ for a 10 MHz signal.
Simulations and measurements confirmed the amplifier's robust phase stability against temperature variations.
Low phase noise and drift performance were observed, suitable for sensitive measurements.

Conclusions:

The developed instrumentation amplifier achieves a high level of phase stability.
This performance approaches the precision required for advanced biomedical applications, including the detection of cerebral hemorrhage.
The amplifier is a key enabling component for future MIT-based diagnostic tools.