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Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
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Risk of cerebrovascular events in persons with and without HIV: a Danish nationwide population-based cohort study

Line D Rasmussen1, Frederik N Engsig, Hanne Christensen

  • 1Department of Infectious Diseases, Odense University Hospital, Denmark. linedahlerup@hotmail.com

AIDS (London, England)
|June 8, 2011
PubMed

Insights

HIV infection increases cerebrovascular event (CVE) risk, especially with injection drug use (IDU) and low CD4 counts. Abacavir exposure also elevates risk, but highly active antiretroviral therapy (HAART) does not.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Neurology

Background:

  • HIV infection is associated with various comorbidities.
  • Cerebrovascular events (CVEs) are a significant concern in HIV-infected populations.
  • Understanding risk factors for CVEs in HIV is crucial for patient management.

Purpose of the Study:

  • To assess the risk of CVEs in individuals with HIV.
  • To evaluate the impact of injection drug use (IDU), immunodeficiency, and highly active antiretroviral therapy (HAART) on CVE risk.
  • To investigate the role of specific antiretroviral drugs and family-related factors in CVE development.

Main Methods:

  • A nationwide, population-based cohort study design was employed.
  • Included Danish HIV-infected individuals and a comparison cohort.
  • Incidence rate ratios (IRRs) and time-dependent Cox regression analyses were used to assess risk factors and drug impacts.

Main Results:

  • HIV-infected individuals showed an increased risk of CVEs (IRR 1.60 for non-IDU, 3.94 for IDU).
  • Low CD4 cell count (<200 cells/μl) and abacavir exposure increased CVE risk.
  • HAART, protease inhibitors, indinavir, didanosin, and tenofovir did not significantly impact CVE risk.

Conclusions:

  • HIV-infected individuals face a higher risk of CVEs, influenced by IDU, low CD4 count, and abacavir.
  • HAART does not appear to increase CVE risk.
  • Family risk factors are generally not associated with CVEs, except in parents of IDU HIV-infected individuals.
Abstract

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