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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Published on: November 21, 2014

Activation of polyphosphoinositide hydrolysis in T cells by H-2 alloantigen but not MLS determinants

A M O'Rourke1, M F Mescher, S R Webb

  • 1Division of Membrane Biology, Medical Biology Institute, La Jolla, CA 92037.

Science (New York, N.Y.)
|July 13, 1990
PubMed

Murine minor lymphocyte-stimulating (Mls) determinants are cell surface antigens that stimulate strong primary T cell responses; the responding T cells display restricted T cell receptor (TCR) V beta gene usage. Interaction of T cells with mitogens or major histocompatibility complex (MHC) antigens activated the polyphosphoinositide (PI) signaling pathway, but this pathway was not triggered by Mls recognition. However, interleukin-2 (IL-2) secretion and proliferation to all three stimuli were comparable. Thus, although recognition of both allo-H-2 and Mls determinants is thought to be mediated by the TCR, these antigens appear to elicit biochemically distinct signal transduction pathways.

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