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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Notch signaling in mammalian hematopoietic stem cells
K V Pajcini1, N A Speck, W S Pear
1The Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
Leukemia
|June 8, 2011
Summary
Notch signaling is vital for mammalian stem cell development. This review details its role in hematopoietic stem cell (HSC) emergence, maintenance, and function throughout life.
Area of Science:
- Developmental Biology
- Cell Signaling
- Hematopoiesis
Background:
- Notch signaling is a fundamental cell-cell communication pathway essential for metazoan development.
- It regulates critical cellular processes including identity, proliferation, differentiation, and apoptosis.
- Recent research highlights Notch's significance in the development and maintenance of mammalian stem cell populations.
Purpose of the Study:
- To review the role of Notch signaling in the development and maintenance of mammalian hematopoietic stem cells (HSCs).
- To explore HSC emergence, development, and homeostasis during embryogenesis and adulthood.
- To connect Notch signaling pathways to established hematopoietic biology.
Main Methods:
- Literature review of studies on Notch signaling and HSCs.
- Analysis of developmental and homeostatic processes in mammalian embryogenesis and adulthood.
- Synthesis of findings regarding Notch's influence on hematopoietic stem cell biology.
Main Results:
- Notch signaling plays a critical role in the emergence and development of HSCs.
- The pathway is essential for maintaining HSC self-renewal and multi-lineage differentiation potential.
- Notch signaling contributes to the long-term homeostasis of the hematopoietic system.
Conclusions:
- Notch signaling is indispensable for the proper formation and function of hematopoietic stem cells.
- Understanding Notch's role in HSCs offers insights into hematopoietic system development and potential therapeutic strategies.
- This pathway is a key regulator of stem cell biology from embryonic development through adulthood.
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03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:01Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
01:19Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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