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XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis
1Department of Urology, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
The X-ray repair cross-complementing group 1 gene (XRCC1) Arg399Gln polymorphism may increase prostate cancer risk in Asian men, but not overall. The Arg194Trp polymorphism showed no significant association with prostate cancer risk in any population.
Area of Science:
- Genetics
- Cancer Epidemiology
- Molecular Biology
Background:
- The X-ray repair cross-complementing group 1 (XRCC1) gene plays a crucial role in DNA repair pathways.
- Polymorphisms in XRCC1, specifically Arg399Gln and Arg194Trp, have been investigated for their association with prostate cancer (PCa) risk.
- Existing studies present conflicting results regarding the link between these XRCC1 polymorphisms and PCa susceptibility.
Purpose of the Study:
- To conduct a meta-analysis to clarify the association between XRCC1 Arg399Gln and Arg194Trp polymorphisms and prostate cancer risk.
- To provide a more precise estimation of the risk conferred by these genetic variations.
Main Methods:
- A comprehensive literature search was performed to identify relevant case-control studies.
- Meta-analysis techniques were employed, using odds ratios (ORs) and 95% confidence intervals (CIs) to quantify the association.
- Stratified analyses were conducted based on ethnicity.
Main Results:
- Overall, neither the XRCC1 Arg399Gln nor the Arg194Trp polymorphism was significantly associated with an increased risk of prostate cancer.
- Stratified analysis revealed a significant association between the XRCC1 Arg399Gln polymorphism and prostate cancer risk specifically in the Asian population.
- The 399Gln allele suggested a potential low-penetrant risk factor for PCa in Asian men.
Conclusions:
- The XRCC1 Arg399Gln and Arg194Trp polymorphisms are not generally associated with overall prostate cancer risk.
- The XRCC1 Arg399Gln polymorphism may represent a modest risk factor for prostate cancer in Asian populations.
- Further research is warranted to elucidate the specific mechanisms and ethnic variations in XRCC1's role in prostate cancer development.
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