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Prostatic comedocarcinoma: correlation of sonograms with pathologic specimens in three cases
R Lile1, D Thickman, G J Miller
1Department of Radiology, University of Colorado Health Sciences Center, Denver 80262.
AJR. American Journal of Roentgenology
|August 1, 1990
Summary
A unique ultrasound finding, a hypoechoic prostate lesion with stippled echogenicity, may indicate aggressive comedocarcinoma. This distinctive sonographic appearance was linked to this specific cancer variant in a patient study.
Area of Science:
- Urology
- Radiology
- Oncology
Background:
- Prostate cancer diagnosis relies on imaging and histopathology.
- Comedocarcinoma is an aggressive variant of prostate cancer requiring accurate detection.
Purpose of the Study:
- To identify unique sonographic features associated with prostate comedocarcinoma.
- To evaluate the diagnostic utility of transrectal ultrasound in detecting this specific prostate cancer subtype.
Main Methods:
- Retrospective review of transrectal ultrasound (TRUS) sonograms from 27 patients undergoing prostatectomy.
- Correlation of sonographic findings with whole-mount histopathologic sections.
- Analysis of sonographic characteristics, specifically echogenicity patterns.
Main Results:
- Three patients exhibited a distinctive sonographic pattern: a hypoechoic lesion with stippled hyperechogenicity.
- Histopathology confirmed comedocarcinoma in these three patients (Gleason pattern 5).
- The remaining 24 patients lacked this sonographic finding and did not have comedocarcinoma.
Conclusions:
- A hypoechoic prostate lesion with diffuse, stippled echogenicity may be a specific sonographic marker for comedocarcinoma.
- Transrectal ultrasound may aid in identifying this aggressive prostate cancer variant prior to surgery.