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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
Optical coherence tomography in dermatology: technical and clinical aspects
Thilo Gambichler1, Volker Jaedicke, Sarah Terras
1Department of Dermatology, Ruhr-University Bochum, Germany. t.gambichler@klinikum-bochum.de
Archives of Dermatological Research
|June 8, 2011
Summary
Optical coherence tomography (OCT) is a non-invasive imaging technique providing high-resolution, depth-resolved visualization of skin microstructures. This review highlights OCT
Area of Science:
- Dermatology
- Medical Imaging
- Biophotonics
Background:
- Optical coherence tomography (OCT) is an emerging non-invasive imaging technique.
- It utilizes infrared radiation and Michelson interferometry for real-time, in vivo visualization.
- OCT offers high-resolution, depth-resolved imaging of tissue microstructures.
Purpose of the Study:
- To review the technical aspects of OCT methods.
- To illustrate the clinical applications of OCT in dermatology.
- To provide evidence for OCT's utility in diagnosing and monitoring skin disorders.
Main Methods:
- Review of existing literature on OCT in dermatology.
- Description of OCT's underlying principles (Michelson interferometry).
- Illustration of OCT's capability in visualizing normal skin structures (epidermis, dermis, etc.).
Main Results:
- OCT provides high-resolution (micrometer scale) cross-sectional images of skin.
- It visualizes subsurface structures like the epidermis, dermis, hair follicles, and blood vessels.
- OCT has demonstrated precision in diagnosing and monitoring skin conditions, including malignancies and inflammatory disorders.
Conclusions:
- OCT is a valuable tool for in vivo skin imaging in clinical settings.
- Its technical variants offer precise diagnostic and monitoring capabilities for various dermatological conditions.
- This review underscores the significance of OCT in modern dermatology practice.
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