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Complexation and medium effects on the conformation of cyclosporin A studied by NMR spectroscopy and molecular
1Institut für Organische Chemie, J.W. Goethe-Universität, Frankfurt am Main, F.R.G.
Biochemical Pharmacology
|July 1, 1990
Abstract:
The conformation of cyclosporin A was investigated in different environments. Whereas there was no distinct difference between the structure of CSA in CDCl3 and THF, the addition of LiCl caused a conformational change. Also, using polar solvents (DMSO, water) induced conformational changes in the backbone as well as the side chains.