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Frequency and severity of headache is worsened by Interferon-β therapy in patients with multiple sclerosis

F Patti1, A Nicoletti, A Pappalardo

  • 1Department of Neurosciences, University of Catania, Italy.

Acta Neurologica Scandinavica
|June 9, 2011
PubMed
Abstract

Insights

Interferon-beta (IFNβ) treatment for multiple sclerosis (MS) can worsen existing headaches or cause new ones. Certain IFNβ preparations, like Rebif® 44 and Avonex®, appear more likely to cause headaches.

Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • The association between multiple sclerosis (MS) and headache (HA) requires further elucidation.
  • Previous reports suggest interferon-beta (IFNβ) may trigger or exacerbate headaches in MS patients.

Purpose of the Study:

  • To assess the impact of IFNβ therapy on headache occurrence and characteristics in mildly disabled MS patients.
  • To investigate the relationship between different commercial IFNβ formulations and headache incidence/severity.

Main Methods:

  • A questionnaire-based study involving 357 relapsing-remitting MS patients.
  • Detailed assessment of headache characteristics, including temporal correlation with IFNβ administration.

Main Results:

  • Of 314 patients with headaches, 219 had pre-existing headaches; 55% reported worsening after IFNβ initiation.
  • New-onset headaches were reported by 95 patients.
  • Headache worsening was more common with Avonex® and Rebif® 44 compared to other IFNβ preparations.

Conclusions:

  • IFNβ treatment is associated with headache exacerbation in patients with pre-existing headaches and the development of new headaches.
  • Avonex® and Rebif® 44 demonstrated a higher propensity for causing headaches (cephalalgic effect) compared to other IFNβ drugs studied.

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