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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

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Does excess body fat maintained after the seventh decade decrease life expectancy?

Pramil N Singh¹, Ella Haddad, Serena Tonstad

¹Department of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, Loma Linda, California 92350, USA. psingh@llu.edu

Journal of the American Geriatrics Society

|June 9, 2011

Summary

This summary is machine-generated.

Excess body fat in older adults, particularly men, is linked to shorter life expectancy and increased mortality risk. This association persists even in healthy individuals, suggesting adiposity is a significant factor in longevity.

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Area of Science:

Gerontology
Epidemiology
Public Health

Background:

The
attenuation in risk of death associated with excess body fat in older adults is often observed.
However, confounding factors may influence this relationship.

Purpose of the Study:

To investigate the relationship between adiposity and mortality in a carefully selected cohort.
To determine if excess body fat, independent of other risk factors, impacts longevity in older adults.

Main Methods:

A prospective cohort study involving 6,030 adults (aged 25-82) who never smoked and had no major chronic diseases.
Follow-up over 29 years with anthropometric data collection and mortality surveillance.
Survival analysis using attained age as the time variable.

Main Results:

Higher body mass index (BMI) was associated with increased mortality risk in both men and women after age 75.
In men aged 75-99, a BMI > 22.3 kg/m² was linked to a 3.7-year shorter life expectancy and significantly greater mortality.
In women aged 75-99, a BMI > 27.4 kg/m² was associated with a 2.1-year shorter life expectancy and increased mortality.

Conclusions:

Sustained excess body fat after age 70 reduces life expectancy.
The detrimental effect of excess body fat on longevity appears less pronounced in women compared to men.