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Updated: Jun 1, 2026

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Published on: August 31, 2022

Liao ning virus in China.

Zhi Lu¹, Hong Liu, Shihong Fu

¹State Key Laboratory for Infectious Disease prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Virology Journal

|June 9, 2011

Summary

Liao ning virus (LNV), a mosquito-borne virus, shows rapid evolution and wide distribution in northern China. Phylogenetic analysis reveals geographic clustering of 46 Chinese LNV isolates.

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Area of Science:

Virology
Molecular Biology
Epidemiology

Background:

Liao ning virus (LNV) belongs to the Seadornavirus genus (Reoviridae family), possessing a 12-segment dsRNA genome.
Transmitted by mosquitoes, LNV has been exclusively isolated in China and is unique within its genus for propagation in mammalian cell lines.

Purpose of the Study:

To report 41 new LNV isolates from Xinjiang, China.
To describe phylogenetic relationships among 46 Chinese LNV isolates.

Main Methods:

Phylogenetic analysis using partial nucleotide sequences of the 10th genome segment (encoding outer coat proteins).
Bayesian coalescent analysis to estimate the most recent common ancestor and evolutionary rates.

Main Results:

Phylogenetic analysis grouped isolates into 3 clusters, correlating with geographic origin.
The most recent common ancestor for Chinese LNV isolates was estimated at 318 years ago.
Evolutionary rate was calculated at 1.993 × 10-3 substitutions per site per year.

Conclusions:

LNV demonstrates rapid evolution and widespread distribution in northern China.
The findings suggest LNV may be an emerging virus.